High altitude pulmonary edema susceptibility gene, Qinghai University

what people on the plateau vulnerable to high altitude pulmonary edema (HAPE), how to carry out effective screening, is a difficult problem for international plateau medical workers have long been expected to solve. Yang Yingzhong of the Qinghai University research group after five years of research found that susceptibility genes of HAPE, for the first time from the gene level reveals the cause of a low altitude people susceptible to the HAPE part, and find the susceptible gene, the theory on the implementation of the HAPE can be screened, which laid the foundation for the practical application. Related research results from the United States, the American Journal of field and environmental medicine, Greece, the Journal of experimental and therapeutic medicine and other international publications. June 8th, the Qinghai provincial science and Technology Department organized experts to identify the subject, that the results reached the international advanced level.

Yang Yingzhong research group based on the National Natural Science Fund Project "EPAS1 gene polymorphism and HAPE correlation", the provincial science and Technology Department of the project "HIF2A gene polymorphism and HAPE correlation" two items of HAPE, from genomics, plasma proteomics and other aspects of the in-depth study, to explore the pathogenesis of HAPE in molecular the search for susceptibility genes.

research group for the first time found that HAPE patients with EPAS1 gene highly correlated. Because HAPE is a complex disease specific to environmental hypoxia, the research group for the first time using a genome-wide association study of large samples, found closely related genes in the pathophysiological process of HAPE; the first choice of whole exome capture and Solexa sequencing platform to find genes associated with HAPE mainly in transcriptional regulation, signal transduction and immune regulation, inflammatory injury process, provide a useful information of 26 SNP loci were screened for genetic research HAPE. In addition, it is the first time that the changes of apolipoprotein A-I and A-IV are related to the occurrence of HAPE, so that apolipoprotein A-I and A-IV may be a biomarker for the risk of HAPE.

That the evaluation results of

international well-known medical experts plateau, Qinghai University research center director Professor in plateau medicine, HAPE happens to the plateau or highland populations in the plains people first entering the higher altitude, the results of the screening can be found HAPE susceptible, effectively eliminate the plateau plain builders fear, provide the scientific method for the screening of high altitude HAPE susceptible population, will play an important role in the plateau of economic and social development and national defense construction.

 

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